Mohamed A. Noor
- Center for Theoretical & Mathematical Sciences
- French Family Science Center 4214
- Campus Box 90338
- Phone: 919-613-8156
- Fax: 919-660-7293
Speciation and evolutionary genetics, recombination
One of the greatest unsolved questions in biology is how continuous processes of evolutionary change produce the discontinuous groups known as species. My research has focused on understanding the processes that cause the evolution of barriers to gene exchange between diverging species, particularly hybrid sterility and species mating discrimination. My approaches are primarily classical or molecular genetic using Drosophila species as model organisms. Using these approaches, we have dissected the genetic basis of these barriers to gene exchange using molecular markers and QTL mapping methodologies or gene expression approaches.
The recent availability of multiple whole-genome sequences (both publicly and those we have obtained ourselves) has dramatically enhanced the scope of progress we can make. In addition to questions in speciation, we have recently been studying the effects of fine-scale recombination heterogeneity on various evolutionary parameters including nucleotide diversity, divergence, and codon bias.
See my lab web page for more information.